Preclinical data with tasquinimod in MDS to be presented at ASH 2022
Lund, November 3, 2022 – Active Biotech (NASDAQ STOCKHOLM: ACTI) today announced that an abstract with preclinical data on tasquinimod, a small molecule immunomodulator, in myelodysplastic syndrome (MDS), has been accepted for presentation at the 64th American Society of Hematology Annual Meeting in New Orleans, Louisiana, December 10-13, 2022 (ASH 2022). The ASH 2022 abstracts were released today, November 3rd, 2022.
The abstract, titled Targeting S100A9 in the Inflammatory Myelodysplastic Hematopoietic Niche Reprograms the Functional Properties of CD271+ Mesenchymal Stromal Cells will be presented by Dr. Manja Wobus, University Hospital Dresden, Germany.
The abstract is the result of a collaboration between Active Biotech and an academic group in Dresden, Germany which aims at addressing the unmet medical need to treat MDS. The presented data show that a subpopulation of mesenchymal stromal cells, i.e. CD271+ MSC’s, is responsible for the diminished hematopoietic support. Tasquinimod modulates the function of these cells and thereby enhances their potential to support hematopoiesis in vitro.
“These new preclinical results suggest that tasquinimod treatment has the potential to increase the hematopoiesis in MDS patients. We are exited to get the opportunity to present our data at such a prestigious conference as ASH, which manifests the external scientific interest in the project,” said Helén Tuvesson, CEO of Active Biotech.
Information on the presentation:
P 1753. Targeting S100A9 in the Inflammatory Myelodysplastic Hematopoietic Niche Reprograms the Functional Properties of CD271+ Mesenchymal Stromal Cells. Poster session 636. Myelodysplastic Syndromes – Basic and Translational: Poster I. Dec 10, 2022, 5:30-7:30 PM. Ernest N. Morial Convention Center, Hall D. Dr. M. Wobus et al., University Hospital Dresden, Germany.
The accepted abstract will be available on the ASH website from 9:00 am Eastern Daylight Time (2:00pm Central European Time) on November 3, 2022.
This information was submitted for publication, through the agency of the contact person set out above, at 15.00 pm CET on November 3, 2022.