RhuDex™

The RhuDex^TM project (including publications from MediGene AG which has licensed the project from Active Biotech)

Discovery of Selective Small-Molecule CD80 Inhibitors
K Uvebrant, D da Graca Thrige, A Rosén, M Åkesson, H Berg, B Walse and P Björk.
J. Biomol. Screen. 12, 2007, 464-472.

New therapeutics that threat rheumatoid arthritis by blocking T-cell activation
N MacKenzie. Drug Disc. Today, 11, 2006, 952-956.

Identification of Protein-Protein Interfaces Implicated in CD80-CD28 Costimulatory Signaling
P Sørensen, M Kussmann, A Rosén, K L Bennett, D da Graca Thrige, K Uvebrant, B Walse, P Roepstorff and P Björk. J Immunol. 172, 2004, 6803-6809.

Blocking T-cell activation in rheumatoid arthritis
P Debnam, P Huxley, D da Graca Thrige and J Abery. Biacore/Avidex article for CDD Dec 03.

High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy
P Huxley, D H Sutton, P Debnam, I R Matthews, J E Brewer, J Rose, M Trickett, D D Williams, T B Andersen and B J Classon. Chemistry & Biology Vol. 11, 1651-1658, December 2004.